Analysis of the Human T Cell Response to HTLV-III (AIDS)
Annual rept. 1 Jul 1987-30 Jun 1988
DANA-FARBER CANCER INST BOSTON MA
Pagination or Media Count:
Acquired Immune Deficiency Syndrome is marked by a collapse in immune responses, particularly those mediated by thymus-derived T lymphocytes. Nevertheless, the presence of antibodies to the AIDS virus HIV indicates the presence of virus specific T cells. In the course of attempting to expand virus specific T cells from HIV seropositive patients, we have determined that the immunomodulator interferon is capable of containing T cell responses in patients with AIDS. These effects occur for T cells responsive to both mitogens and antigens, but only in moderately advanced no in far advanced disease. Keywords Vaccine development, Cellular immunity, Human immunodeficiency virus, Virology, Monoclonal antibody, Anti-idiotype antibody, Lab animals, Rats, Volunteers. AIDS, Acquired Immune Deficiency.
- Medicine and Medical Research