Accession Number:

ADA200003

Title:

Analysis of the Human T Cell Response to HTLV-III (AIDS)

Descriptive Note:

Annual rept. 1 Jul 1987-30 Jun 1988

Corporate Author:

DANA-FARBER CANCER INST BOSTON MA

Personal Author(s):

Report Date:

1988-06-30

Pagination or Media Count:

17.0

Abstract:

Acquired Immune Deficiency Syndrome is marked by a collapse in immune responses, particularly those mediated by thymus-derived T lymphocytes. Nevertheless, the presence of antibodies to the AIDS virus HIV indicates the presence of virus specific T cells. In the course of attempting to expand virus specific T cells from HIV seropositive patients, we have determined that the immunomodulator interferon is capable of containing T cell responses in patients with AIDS. These effects occur for T cells responsive to both mitogens and antigens, but only in moderately advanced no in far advanced disease. Keywords Vaccine development, Cellular immunity, Human immunodeficiency virus, Virology, Monoclonal antibody, Anti-idiotype antibody, Lab animals, Rats, Volunteers. AIDS, Acquired Immune Deficiency.

Subject Categories:

  • Biochemistry
  • Medicine and Medical Research
  • Microbiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE