Sickle-Cell Trait as a Risk Factor for Sudden Death in Physical Training
WALTER REED ARMY INST OF RESEARCH WASHINGTON DC
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Case reports of sudden death during exertion have not established an association between the sickle-cell trait hemoglobin AS and exercise-related death. To test this association, all deaths occurring among 2 million enlisted recruits during basic training in the U.S. Armed Forces in 1977 to 1981 were classified from autopsy and clinical records as non-sudden deaths or as sudden deaths explained or unexplained by preexisting disease. we conclude that recruits in basic training with the sickle-cell trait have a substantially increased, age dependent risk of exercise-related sudden death unexplained by any known preexisting cause. Reprints.
- Medicine and Medical Research
- Stress Physiology