Accession Number:

ADA199878

Title:

Neurophysiological Research Supporting the Investigation of Adaptive Network Architectures

Descriptive Note:

Final rept. 1 Jun 1985-31 Jul 1988

Corporate Author:

CALIFORNIA UNIV MEDICAL CENTER LOS ANGELES

Personal Author(s):

Report Date:

1988-05-01

Pagination or Media Count:

100.0

Abstract:

Research demonstrated that rates of learning of a conditioned eyeblink response in cats could be significantly accelerated by adding electrical stimulation of the hypothalamic region of the brain at the appropriate time interval in relation to the conditioning stimuli. This learning model was extended to obtain rapid conditioning of single cortical neurons. Changes in currents in the conditioned cells were detected using the single electrode voltage clamp technique. Long lasting increases in input resistance and excitability similar to those produced by acetylcholine were found after applications of cyclic GMP-dependent protein kinase and cGMP. Keywords Conditioning stimuli Conditioning cortical neurons Acetylcholine. awmjm

Subject Categories:

  • Anatomy and Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE