Accession Number:

ADA199757

Title:

Fiber Optic Microsensor for Receptor-Based Assays

Descriptive Note:

Technical rept. Sep 1986-Mar 1987

Corporate Author:

ORD INC NAHANT MA

Report Date:

1988-09-01

Pagination or Media Count:

23.0

Abstract:

This project established the feasibility of adapting fiber optic fluorescence immunoassay FFIA instrument as a pocket-sized microsensor for rapid receptor-based assays. The instrument, with its light-emitting diode LED source and solid state detector, was demonstrated to satisfy projected sensitivity requirement for a receptor-base assay device. An aqueous solution of fluorescent tag was successfully detected at a noise equivalent concentration NEC in the subpicomolar range. In actual practice, system sensitivity will be limited by biological factors such as the ability of the receptor coating to specifically bind at such low concentrations. Keywords Microsensors Receptor Optical wave.

Subject Categories:

  • Optical Detection and Detectors
  • Fiber Optics and Integrated Optics
  • Biomedical Instrumentation and Bioengineering

Distribution Statement:

APPROVED FOR PUBLIC RELEASE