Characterization of the Ptychodiscus brevis Polyether Neurotoxin Binding Component in Excitable Membranes
Annual rept. 1 Jun 1987-31 May 1988
MIAMI UNIV CORAL GABLES FL
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The research is aimed at characterization of the binding site for Ptychodiscus brevis neurotoxin PbTx-3 formerly known as T17 in nerve tissues, specifically in rat brain synaptosomes. The polyether lipid-soluble toxins isolated from the marine dinoflagellate Ptychodiscus brevis formerly Gymnodinium breve bind to a unique site, Site V, associated with the voltage- sensitive sodium channel probe for binding at Site V, dissociation constants and binding maxima have been determined in rat, fish, and turtle brain synaptosomes. Keywords Binding sites Active sites Membranes biology Sodium channels Brevetoxins Toxins.
- Genetic Engineering and Molecular Biology