Accession Number:

ADA199525

Title:

Characterization of the Ptychodiscus brevis Polyether Neurotoxin Binding Component in Excitable Membranes

Descriptive Note:

Annual rept. 1 Jun 1987-31 May 1988

Corporate Author:

MIAMI UNIV CORAL GABLES FL

Personal Author(s):

Report Date:

1988-07-31

Pagination or Media Count:

29.0

Abstract:

The research is aimed at characterization of the binding site for Ptychodiscus brevis neurotoxin PbTx-3 formerly known as T17 in nerve tissues, specifically in rat brain synaptosomes. The polyether lipid-soluble toxins isolated from the marine dinoflagellate Ptychodiscus brevis formerly Gymnodinium breve bind to a unique site, Site V, associated with the voltage- sensitive sodium channel probe for binding at Site V, dissociation constants and binding maxima have been determined in rat, fish, and turtle brain synaptosomes. Keywords Binding sites Active sites Membranes biology Sodium channels Brevetoxins Toxins.

Subject Categories:

  • Genetic Engineering and Molecular Biology
  • Toxicology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE