Accession Number:
ADA199508
Title:
Mechanism of Cytotoxicity of the AIDS (Acquired Immunodeficiency Syndrome) Virus, HTLV-III/LAV
Descriptive Note:
Annual summary rept. 31 Mar 1987-30 Mar 1988
Corporate Author:
WASHINGTON UNIV ST LOUIS MO
Personal Author(s):
Report Date:
1988-04-21
Pagination or Media Count:
20.0
Abstract:
Understanding the mechanism of human immunodeficiency virus HIV type 1 replication and cytopathicity are critical to determining the pathogenesis and treatment of the acquired immunodeficiency syndrome AIDS and associated diseases. Studies of related viruses, SIV and HIV-2, complement these studies and allow additional animal model systems for testing hypotheses. We have studied three aspects of HIV pathogenesis. First, a mutagenic analysis of HIV-1, SIV, and HIV-2 genes has been performed to decipher their role in replication and cytopathic activity. Second, immunopathogenetic consequences have been studied with respect to the characterization of lymphotoxin-like molecule which is secreted by HIV-1 infected cells. Third, the structure and function of HIV-1 env variation has been studied in a clustered outbreak of HIV- 1 infection to elucidate the role of envelope alterations in immune evasion and tissue tropism. Keywords Genetics, Mutation.
Descriptors:
Subject Categories:
- Biology
- Medicine and Medical Research
- Microbiology