Accession Number:

ADA199508

Title:

Mechanism of Cytotoxicity of the AIDS (Acquired Immunodeficiency Syndrome) Virus, HTLV-III/LAV

Descriptive Note:

Annual summary rept. 31 Mar 1987-30 Mar 1988

Corporate Author:

WASHINGTON UNIV ST LOUIS MO

Personal Author(s):

Report Date:

1988-04-21

Pagination or Media Count:

20.0

Abstract:

Understanding the mechanism of human immunodeficiency virus HIV type 1 replication and cytopathicity are critical to determining the pathogenesis and treatment of the acquired immunodeficiency syndrome AIDS and associated diseases. Studies of related viruses, SIV and HIV-2, complement these studies and allow additional animal model systems for testing hypotheses. We have studied three aspects of HIV pathogenesis. First, a mutagenic analysis of HIV-1, SIV, and HIV-2 genes has been performed to decipher their role in replication and cytopathic activity. Second, immunopathogenetic consequences have been studied with respect to the characterization of lymphotoxin-like molecule which is secreted by HIV-1 infected cells. Third, the structure and function of HIV-1 env variation has been studied in a clustered outbreak of HIV- 1 infection to elucidate the role of envelope alterations in immune evasion and tissue tropism. Keywords Genetics, Mutation.

Subject Categories:

  • Biology
  • Medicine and Medical Research
  • Microbiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE