Accession Number:

ADA199366

Title:

Synthesis of a Moldable Biodegradable Bone Repair Material: Characterization and In Vivo Evaluation of Cross-Linked Poly(Propylene Fumarate)

Descriptive Note:

Final rept. Jan 1983-Sep 1987

Corporate Author:

ARMY INST OF DENTAL RESEARCH WASHINGTON DC

Personal Author(s):

Report Date:

1987-09-01

Pagination or Media Count:

34.0

Abstract:

Biodegradable poly propylene fumarate was synthesized and characterized for application as a moldable bone repair material which could be placed in a bone defect and subsequently cured to a hardened consistency within 30 to 35 minutes. Curing was accomplished by cross-linking with vinyl pyrolidone in the presence of benzoyl peroxide. In vitro degradation studies of the set material did not appear to demonstrate degradation rates conducive to mediating bone repair. In vivo studies were also negative. However, the data suggests that polypropylene fumarate has potential as a moldable bone repair material and further research will be required.

Subject Categories:

  • Medical Facilities, Equipment and Supplies
  • Polymer Chemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE