Accession Number:

ADA199226

Title:

Therapeutic Approaches to the Treatment of Botulism

Descriptive Note:

Annual rept. 1 Sep 1986-31 Aug 1987

Corporate Author:

JEFFERSON MEDICAL COLL PHILADELPHIA PA

Personal Author(s):

Report Date:

1987-10-01

Pagination or Media Count:

35.0

Abstract:

In vitro experiments have been done on isolated phrenic nerve- hemidiaphragm preparations. The purpose of the experiments was twofold firstly, to evaluate a host of drugs as potential botulinum neurotoxin antagonists and secondly, to evaluate the possibility that botulinum neurotoxin is an ADP- ribosyltransferase. The drugs that were tested included aminopyridines, guanidine, calcium, theophylline, forskolin, isobutylmethylxanthine, and cholera toxin. Various of the drugs had effects on neuromuscular transmission, and some had narrow spectrum utility as clostridial toxin antagonists, but none had the broad spectrum utility that would be needed for a clinically useful drug. In related experiments, a series of studies were conducted to determine whether the toxins have ADP-ribosyltransferase activity. The data did not support the hypothesis, though additional work needs to be done.

Subject Categories:

  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE