Accession Number:

ADA199199

Title:

Treatment with Tyrosine, a Neurotransmitter Precursor, Reduces Environmental Stress in Humans

Descriptive Note:

Corporate Author:

ARMY RESEARCH INST OF ENVIRONMENTAL MEDICINE NATICK MA

Report Date:

1988-07-25

Pagination or Media Count:

19.0

Abstract:

Acutely stressful situations can disrupt behavior and deplete brain norepinephrine and dopamine, catecholaminergic neurotransmitters. In animals, administration of tyrosine, a food constituent and precursor of the catecholamines, reduces these behavioral and neurochemical deficits. We invested whether tyrosine 100 mgkg would protect humans from some of the adverse consequences of a 4.5 hour exposure to cold and hypoxia, conditions experienced in high mountainous regions. Tyrosine significantly decreased symptoms, adverse moods, and performance impairments in subjects who exhibited average or greater responses to these environmental conditions. This suggests that treatment with tyrosine should be evaluated in these and other acutely stressful situations for beneficial behavioral effects.

Subject Categories:

  • Stress Physiology
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE