Accession Number:

ADA199196

Title:

Comparative Inhalation Toxicology of Selected Materials. Phase 2.

Descriptive Note:

Final rept. Jan-Jul 1986

Corporate Author:

LOVELACE BIOMEDICAL AND ENVIRONMENTAL RESEARCH INST ALBUQUERQUE NM INHALATION TOXICOLOGY RESEARCH INST

Personal Author(s):

• Snipes, M. B.
• Bice, D. E.
• Burt, D. G.
• Damon, E. G.
• Eidson, A. F.
• Hahn, F. F.
• Harkema, J. R.
• Harmsen, A. G.
• Henderson, R. F.
• Mauderly, J. L.
• Pickrell, J. A.
• Seiler, F. A.
• Yeh, H. C.

Report Date:

1988-05-01

Pagination or Media Count:

188.0

Abstract:

Male and female F344N rats were exposed nose-only to a respirable powder of copper-zinc alloy. No rats died as a result of the exposures. Body weights were reduced relative to sham-exposed rats for rats exposed to 240 and 480 mg. hr Cu-Zncu.m week. All of the additional observed biological responses to inhaled Cu-Zn were restricted to the respiratory tract. Lung weights were increased due to an inflammatory response for rats exposed to 120 mg. hr Cu-Zn cu.m or more per week. Exposure to 240 mg. hr Cu-zncu.m per week caused restrictive pulmonary functional disorder, as evidenced by a reduced lung capacity, reduced quasistatic compliance, reduced carbon monoxide diffusing capacity, and increased percent forced vital capacity exhaled in 0.1 second. Exposure-related responses in lavage fluid indicators of lung damage included increased beta-glucuronidase, increased lactate dehydrogenase, and increases in inflammatory cells, total protein, and collagen. Histological lesions produced by Cu-Zn were atrophy of the nasal olfactory epithelium and hyperplasia of goblet cells in the respiratory epithelium, focal necrotizing alveolitis, alveolar macrophage hyperplasia, and goblet cell hyperplasia of bronchial and bronchiolar epithelium. The inhaled Cu-Zn alloy caused exposure-related inflammatory and cytotoxic responses in the respiratory tract, but the inhaled Cu-Zn cleared rapidly and the responses largely resolved after cessation of exposures.

Descriptors:

• *TOXICITY
• *ZINC ALLOYS
• *COPPER ALLOYS
• CAPACITY(QUANTITY)
• POWDERS
• PROTEINS
• REDUCTION
• WEIGHT
• LUNG
• RESPIRATORY SYSTEM
• CARBON MONOXIDE
• RESPONSE(BIOLOGY)
• RESPIRATION
• CELLS(BIOLOGY)
• INFLAMMATION
• BODY WEIGHT
• LESIONS
• NECROSIS
• HISTOLOGY
• TOXICOLOGY
• COLLAGEN
• INHALATION
• ATROPHY
• RATS
• LACTIC DEHYDROGENASE
• EPITHELIUM
• DAMAGE

Subject Categories:

• Toxicology
• Metallurgy and Metallography

Distribution Statement:

APPROVED FOR PUBLIC RELEASE