Bioassay of Military Relevant Compounds for Carcinogenic Activity by the Strain A Mouse Lung Tumor Bioassay
Final phase rept. 1 Aug 1980-31 Aug 1984
MEDICAL COLL OF OHIO AT TOLEDO DEPT OF PATHOLOGY
Pagination or Media Count:
The Medical College of Ohio conducted studies to determine the carcinogenic potential of a series of dinitrotoluene compounds, diaminotoluenes, dyes, and other selected compounds for carcinogenic activity in the strain A mouse lung tumor bioassay. In most cases, a comparison was made of the carcinogenic potential of the chemicals following either intraperitoneal i.p. or oral p.o., by gavage administration. 2,4-Dinitrotoluene, 2,6- dinitrotoluene, a 21 mixture of 2,4-dinitro-toluene and 2,6-dinitrotoluene did not induce lung tumors in AJ mice at any of the three dose levels given, or by either route of administration. 2,3-Dinitrotoluene, 2,5-dinitrotoluene, 3,4- dinitrotoluene, 3,5-dinitrotoluene, and two dyes used in colored smoke grenades i.e., C.I. Solvent Yellow 33 and a mixture of C.I. Solvent Green 3C.I. Solvent Yellow 33 were also negative for lung tumor induction following i.p. administration. 2,6-Diaminotoluene, a metabolite of 2,6-dinitrotoluene, induced a significant albeit marginal increase in the lung tumor response when given i.p at a total dose of 375 mgkg. After p.o. administration at the same dose, the compound produced an increase in the tumor response, but the increase was not significant. 2,4-Diaminotoluene was negative for lung tumor induction in strain A mice.
- Medicine and Medical Research