Accession Number:

ADA198097

Title:

Toxic Hazards Research Unit Annual Report: 1987

Descriptive Note:

Annual rept. no. 24, Oct 1986-Oct 1987

Corporate Author:

NORTHROP SERVICES INC - ENVIRONMENTAL SCIENCES DAYTON OH

Report Date:

1988-03-01

Pagination or Media Count:

208.0

Abstract:

This report has been prepared as a review of the activities of the Toxic Hazards Research Unit for the period of October 1986 through September 1987. Research activities focused on toxicity evaluations of aerospace and naval chemicals and materials to include hydraulic fluids, lubricating oils, groundwater contaminants, chemical defense simulants and binary agent components. Physiologically based pharmacokineticpharmacodynamic modeling has been developed and provides methods for simulating the toxicological effects of selected chemicals, including models for chemical carcinogenesis. The completion and utilization of the General Toxicology Laboratory within the THRU has resulted in the completion of an increased number of acute and repeated treatment studies, and additional subchronic studies are planned. The objectives of this research program are to identify and characterize the toxic effects of chemicals, compounds, and materials that are of operational interest and concern to the Air Force and Navy. This coordinated USAF-USN program generates scientific information from which simulation and predictive models, experimental design,and risk assessment criteria can be developed. Keywords Alkaline elution, Beryllium oxide, Chloropentafluorobenzene, Carcinogenesis, Chlorotrifluroethylene.

Subject Categories:

  • Toxicology
  • Lubricants and Hydraulic Fluids
  • Chemical, Biological and Radiological Warfare
  • Water Pollution and Control

Distribution Statement:

APPROVED FOR PUBLIC RELEASE