Accession Number:

ADA196898

Title:

Human Granulocyte Surface Molecules Identified by Murine Monoclonal Antibodies

Descriptive Note:

Corporate Author:

MINNESOTA UNIV MINNEAPOLIS DEPT OF MEDICINE

Report Date:

1983-10-01

Pagination or Media Count:

7.0

Abstract:

Macromolecules present on the surface of neutrophilic granulocytes and their progenitor cells have important roles in controlling characteristic functions, such as chemotaxis, phagocytosis, and cellular proliferation. Congenital abnormalities of neutrophils caused by genetic deficiency of specific surface glyco-proteins have been identified. Several well-defined receptors have been demonstrated to appear on the surface of myeloid cell precursors at well- defined stages of differentiation these surface molecules, however, lack lineage specificity, because they are expressed on other hemopoietic cell types. Monoclonal antibodies reacting against the surface antigens of myelomonocytic cells, but not reacting with other normal hemopoietic cells, have been described by several investigators. We here characterize the human granulocyte antigens that most commonly elicit immune response in the mouse and are recognized by a number of monoclonal antibodies that are specific for granulocytes and their precursor cells. We also define the differentiation stage at which each given antigen becomes expressed and define the type of leukemic cell lines on which these antigens are expressed.

Subject Categories:

  • Biochemistry
  • Genetic Engineering and Molecular Biology
  • Medicine and Medical Research
  • Microbiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE