Accession Number:

ADA196843

Title:

Biology of Immunomodulators

Descriptive Note:

Annual rept. 15 Feb 1986-14 Feb 1987

Corporate Author:

SOUTH CAROLINA UNIV COLUMBIA SCHOOL OFMEDICINE

Report Date:

1987-07-01

Pagination or Media Count:

54.0

Abstract:

We have compared effects of Poly IC-LC, CL 24673 and Ampligen on clearance and organ localization of radiolabelled sheep erytorocytes SRBC peritoneal, splenic and liver cell phagocytosis antibody PFC responses splenic and liver natural killer NK cytotoxicity specific T cell cytotoxicity enumeration of lymphoid cell subpopulations macrophage antiviral activity and serum interferon levels. We have also examined the effect of these agents on resistance to herpes, Punta Toro and Banzi virus infections. All three agents tested were capable of stimulating the blood clearance reticuloendothelial function of mice, although the timing of stimulation varied from one drug to other. All three drugs enhanced the NK cytotoxicity and serum interferon levels, although Poly IC-LC had most profound effect on these parameters. Keywords Antiviral agents Macrophages Lymphocytes Banzi virus Encephalitis Herpes Hepatitis.

Subject Categories:

  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE