Accession Number:

ADA196766

Title:

A Preliminary Study of the Osteogenic Potential of a Biodegradable Alloplastic-Osteoinductive Alloimplant

Descriptive Note:

Corporate Author:

WALTER REED ARMY MEDICAL CENTER WASHINGTON DC

Report Date:

1987-06-01

Pagination or Media Count:

42.0

Abstract:

A biodegradable copolymer of polylactidepolyglycolide PLAPGA was combined with allogeneic decalcified freeze-dried bone DFDB and implanted into 15 mm diameter defects in the calvaria of 26 New Zealand White rabbits. Similar defects were created in the calvaria of another 26 rabbits. These animals served as controls and did not receive copolymer implants. Upon sacrifice, both the implants and the controls were evaluated clinically, radiographically, and histomorphometrically using a Zeiss Image Analysis System. Both controls and implants were evaluated in groups at 4, 8, 12, 16, 20, and 24 weeks. When compared with the control defects, the copolymerDFDB implants displayed a significantly greater volume of trabecular bone. Three of the 15 mm diameter defects displayed evidence of complete osseous bridging at 8 weeks. No adverse host tissue responses were observed histologically in any of the implant specimens. Keywords Bone regeneration, Bone fracture repair, Surgical implants.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research
  • Polymer Chemistry
  • Miscellaneous Materials

Distribution Statement:

APPROVED FOR PUBLIC RELEASE