Study of Nephropathia Epidemica in Sweden
Final rept. 21 Nov 1985-26 Nov 1987,
NATIONAL BACTERIOLOGICAL LAB STOCKHOLM (SWEDEN)
Pagination or Media Count:
The incidence of Nephropathia Epidemica NE was determined for various regions of Sweden and compared with the NE antibody prevalence rates in normal population. An incidence of 29 cases per 100.000 population and year was recorded in the most highly endemic area where the antibody prevalence rates exceeded 20 in older age-groups. Approximately 14-20 NE infections per hospitalized case of NE occurred for men and women, respectively. A u-capture ELISA was developed and proved useful as a rapid diagnostic tool. An immunoglobin G IgG ELISA was also developed and compared with IFT. Antigenic relationships between different Hanta-viruses were analyzed by IFT and RIPA. Isolates originating from Scandinavia, Belgium and western U.S.S.R. were indistinguishable. Clethrionomys glareolus was found to be the most abundant rodent, as well as the species most frequently found positive. Antibody positive voles were restricted to the northern two thirds of the country, an area corresponding to that where human cases occur.