Dinoflagellate Toxins Responsible for Ciguatera Food Poisoning
Annual summary rept. 1 Dec 1986-30 Nov 1987
SOUTHERN ILLINOIS UNIV AT CARBONDALE LAB OF APPLIED PHYSIOLOGY
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Ciguatera is a syndrome occurring in humans who have become intoxicated from eating poison fish. Fish spontaneously accumulate the toxin through the food chain or directly from eating toxic dinoflagellates. Previous research points to the presence of multiple toxin involvement. In addition to the establishment of facilities, this contract requires the growth of sufficient quantities of three different species of dinoflagellates to allow purification of milligram quantities of toxins for delivery to the U.S. Army Medical Research and Development Command. In this first year of the contract, necessary personnel were acquired and equipment set up to grown the dinoflagellate, Gambierdiscus toxicus in mass culture. Purification of the products of these cultures is in progress.