Accession Number:

ADA193629

Title:

Physiological Mechanisms of Acute Intestinal Radiation Death

Descriptive Note:

Technical rept. 1 Jun 1983-1 Jun 1986

Corporate Author:

WASHINGTON UNIV SEATTLE DEPT OF ENVIRONMENTAL HEALTH

Personal Author(s):

• Jackson, Kenneth L.
• Geraci, Joseph P.

Report Date:

1986-06-01

Pagination or Media Count:

117.0

Abstract:

The overall objective was to clarify the role of fluid and electrolyte loss, bile-duct ligation, radiation-damaged intestinal mucosa, bacterial toxemia and their interrelationships on radiation-induced gastrointestinal death. Using specific pathogen-free CD-1 male rats, this study found that endogenous enteric bacteria did not play a significant role in pure intestinal radiation death. Bile acids, per se, were shown to play little role in intestinal radiation death but that the inability of the denuded mucosa to absorb fluid and electrolytes, thereby producing hypovolemic shock was the major mechanism. Keywords Neutron exposure Gamma ray exposure.

Descriptors:

• *INTESTINES
• *RADIATION EFFECTS
• RADIATION
• PURITY
• GAMMA RAYS
• FLUIDS
• PHYSIOLOGY
• WOUNDS AND INJURIES
• EXPOSURE(PHYSIOLOGY)
• MUTAGENS
• DEATH
• NEUTRONS
• BACTERIAL DISEASES
• TRAUMATIC SHOCK
• GASTROINTESTINAL SYSTEM
• BILE
• ELECTROLYTES(PHYSIOLOGY)
• TOXEMIA

Subject Categories:

• Radiobiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE