Accession Number:

ADA193339

Title:

Neurological Consequences of Acute and Chronic Cholinergic Blockage.

Descriptive Note:

Annual rept. 1 Jun 85-31 May 86,

Corporate Author:

MICHIGAN UNIV ANN ARBOR

Personal Author(s):

• Domino, Edward F.

Report Date:

1986-06-02

Pagination or Media Count:

60.0

Abstract:

Various selective and nonselective M1 and M2 cholinergic antagonists have been studied for their presynaptic effects on 3H-acetylcholine release from the rat brain hippocampal slice preparation. Marked differences in potency and efficacy were observed that have direct implications with regard to the treatment of organophosphate poisoning. Keywords Antidotes.

Descriptors:

• *ANTIDOTES
• *NERVE BLOCKING
• *CHOLINESTERASE INHIBITORS
• BRAIN
• ORGANOPHOSPHATES
• POISONING
• RATS
• SYNAPSE
• CHOLINERGIC NERVES
• HIPPOCAMPUS
• PHARMACOLOGICAL ANTAGONISTS
• ATROPINE

Subject Categories:

• Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE