Accession Number:

ADA193139

Title:

Primary Screening of Potential Radioprotective Agents.

Descriptive Note:

Annual rept. 30 Sep 86-29 Sep 87,

Corporate Author:

LOUISVILLE UNIV KY DEPT OF RADIATION ONCOLOGY

Personal Author(s):

• Sigdestad, Curtis P.

Report Date:

1987-10-01

Pagination or Media Count:

52.0

Abstract:

This report deals with primary screening of potential radiation protective agents. The drugs to be tested were provided by the U.S. Army Medical Research and Development Command, Fort Detrick, Maryland. The compounds were tested in toxicity screens to determine the maximum tolerated dose MTD effects. Limited available drug amounts precluded more refined testing. The second screen involved Cobalt-60 gamma radiation. The agents to be tested were injected intraperitoneally into CDI female Swiss mice, thirty minutes prior to irradiation with either 9.0 or 9.5 Gy. The latter value was found to be the radiation LD10030 for this mouse strain. Survival was measured and the degree of protection was determined. Dose modification factors were determined on a limited number of agents as directed by the COR. Keywords Radiobiology, Radiation protective agents, Low LET radiation, Protectors, Mice, Drug development, Drug effects.

Descriptors:

• *RADIOPROTECTIVE AGENTS
• ARMY RESEARCH
• DOSAGE
• FEMALES
• IRRADIATION
• MEDICAL RESEARCH
• MICE
• MODIFICATION
• RADIOBIOLOGY
• SURVIVAL(GENERAL)
• TEST AND EVALUATION
• GAMMA RAYS
• COBALT
• RADIOACTIVE ISOTOPES
• SUBLETHAL DOSAGE

Subject Categories:

• Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE