Accession Number:

ADA193138

Title:

Pharmacologic Studies on the In Vitro Bronchodilating Vasoactive Actions of Oligo-PGB (Prostaglandin B)

Descriptive Note:

Final rept. 1 Aug 1986-31 Dec 1987

Corporate Author:

WISCONSIN UNIV-MADISON DEPT OF ANESTHESIOLOGY

Report Date:

1988-01-06

Pagination or Media Count:

18.0

Abstract:

Oligomeric mixtures of prostaglandin B1 O-PGB relaxes airways of guinea pig when studied in vitro. Bronchi with the epithelium preserved or removed were exposed to contractile agent for 20 minutes either in presence or in absence of indomethacin .000005 M. O-PGB was added at .000001 and .00001 M when present, and the results were defined in terms of percent of maximum relaxation induced by papaverine .001 M. Substance P SP 3 x 10 to the -8th M, leukotriene D4 LTD4 1 x 10 to the -9th M and carbachol 1 x 10 to the -8th M induced similar contractions. Keywords Oligo-PGB, Bronchodilatation, Hypersensitive response.

Subject Categories:

  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE