Accession Number:

ADA193124

Title:

Histopathological Changes in Gastrocnemius Muscles of Rabbits Injected with HI-6 in Saline

Descriptive Note:

Memorandum rept.

Corporate Author:

DEFENCE RESEARCH ESTABLISHMENT SUFFIELDRALSTON (ALBERTA)

Report Date:

1988-02-01

Pagination or Media Count:

25.0

Abstract:

The gastrocnemius muscles of rabbits were injected with HI-6 in saline. Macroscopic and histopathological examinations of injection sites and regional lymph nodes revealed that HI-6 in saline produced muscle necrosis. Macroscopic examinations of muscles injected with a low dose of HI-6 50 mgkg showed no lesions on Day 7. However, histopathological examinations disclosed lesions on some animals but with evidence of healing processes by Day 7 lesions disappeared by Day 14. Further macroscopic and histopathological examinations revealed that lesions associated with the high dose 200 mgkg were still prominent on Day 14 but with evidence of healing. Similar lesions seen in muscles injected with saline were significantly less persistent than those associated with HI-6. Keywords Oximes, Pyridinium dichlorides, Chemotherapeutic agents, Chemical warfare agents Antidotes.

Subject Categories:

  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE