A Study of the Nephrotoxicity and Metabolism of Tetralin and Indan in Fischer 344 Rats.
Annual rept. 1 Feb 87-31 Jan 88,
WRIGHT STATE UNIV DAYTON OHIO DEPT OF CHEMISTRY
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A group of male and female 344 rats were dosed with tetralin over a 14 day period. Histopathology of the kidneys revealed significant damage to the renal tubules of the dosed male rats compared to control male rats dosed with water. Both groups of female rats dosed with tetralin or water showed no kidney damage. The urine metabolites of tetralin identified from both male and female rats included 1-tetralol, 2-tetralol, 2-hydroxy-1-tetralone, 4-hydroxy-1-tetralone, 1,2-tetralindiol and 1,4-tetralindiol. No metabolites of tetralin were isolated from the kidney extracts of dosed animals. Keywords Hydrocarbon nephrotoxicity, Tetralin metabolism.