Accession Number:

ADA191985

Title:

United States Air Force Personnel and Exposure to Herbicide Orange

Descriptive Note:

Interim rept. Mar 1984-Feb 1988

Corporate Author:

SCHOOL OF AEROSPACE MEDICINE BROOKS AFB TX

Personal Author(s):

Report Date:

1988-02-01

Pagination or Media Count:

38.0

Abstract:

The United States Air Force is conducting an epidemiological study, called the Air Force Health Study AFHS, to determine whether or not military personnel associated with herbicide spraying during the Vietnam War have experienced any adverse health effects. This report reviews salient findings of the AFHS first morbidity report published in 1984, and presents new work by examining relationships between AFHS findings and the results of laboratory toxicological studies and other epidemiological studies addressing dioxin. Eleven clinical areas have been emphasized based on a toxicological profile developed from the literature and availability of data in the AFHS weight loss, neoplasia, birth defects, neurological changes, psychological changes, hepatotoxicity, chloracne, cardio-vascular changes, immunological deficits, endocrine changes, and mortality. In six of these eleven clinical areas, statistically significant group differences occurred, and in five of these six instances the group differences were in the direction of expected dioxin effects. Dioxin cannot be confidently identified as the causative agent of these findings at this time because of several reasons, including the absence of correlations with an exposure index and the incomplete clinical picture. However, dioxin is not exonerated as a causative agent because of the directionality of the observed group differences and the preliminary nature of the exposure index used in the AFHS first morbidity report.

Subject Categories:

  • Medicine and Medical Research
  • Toxicology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE