Accession Number:

ADA191983

Title:

Intraerythrocytic Killing of Malaria Parasites.

Descriptive Note:

Annual rept. 1 Aug 86-31 Jul 87,

Corporate Author:

NEW YORK UNIV MEDICAL CENTER N Y

Personal Author(s):

• Shear, Hannah L.

Report Date:

1987-09-30

Pagination or Media Count:

28.0

Abstract:

The purpose of these studies is to determine the role of activated macrophages in immunity to the blood stages of malaria. This is being accomplished by comparing the activity of macrophages during lethal and non-lethal malaria infections and in malaria-resistant and non-resistant mice. The results indicate that in non-lethal P. yoelii infection of mice, macrophage activity, as determined by H2O2 release, gamma-interferon production and lymphoproliferation, is high early in infection, declines during the time of peak parasitemia and recovers as the infection is cleared. Although some macrophage functions are enhanced during the early phase of lethal P. yoelli infection, this enhancement is not sustained. Recombinant gamma-interferon, infected into mice, had a protective effect in susceptible mice with lethal infections but not in non-lethal infections. Keywords Erythrocytes Pathology.

Descriptors:

• *ERYTHROCYTES
• *MALARIA
• *PATHOLOGY
• *PHAGOCYTES
• *IMMUNOCHEMISTRY
• *PLASMODIUM
• ACTIVATION
• BLOOD
• FUNCTIONS
• IMMUNITY
• INFECTIOUS DISEASES
• LETHALITY
• MICE
• PARASITEMIAS
• PARASITES
• PROTECTION
• RETICULOENDOTHELIAL SYSTEM
• HYDROGEN PEROXIDE
• INTERFERON

Subject Categories:

• Anatomy and Physiology
• Microbiology
• Biochemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE