Genetic and Serological Analysis of Salmonella-coli Phage Hybrids and Development of New Mutator Phages with Expanded Host Ranges.
Final rept. 1 Nov 84-30 Jun 87, annual rept. 1 Nov 85-30 Jun 87,
HAHNEMANN UNIV SCHOOL OF MEDICINE PHILADELPHIA PA
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Hybrids between Salmonella phage P22 and coli mutator phage Mu have been isolated, using their common hosts Escherichia coli - S. typhimurium recombinants. Although these evolutionary distant phages P22 and Mu have no genetic homology and totally different gene organizations and genomic structures, hybrids were found at an extremely low frequency. The MuimmP22 hybrid class carriers the entire late genes of Mu and some early genes at least the c region of P22. P22 grows in strains lysogenic for MuimmP22 though it carries the c region of P22. Keywords Genetics Gene mapping.
- Genetic Engineering and Molecular Biology