Response of Bioluminescent Bacteria to Alkyltin Compounds.
Professional paper for period ending Sep 87,
NAVAL OCEAN SYSTEMS CENTER SAN DIEGO CA
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The reduction of light intensity in bioluminescent bacteria upon exposure to toxic substances can be used for rapid screening of materials. Results are often comparable to more expensive standard bioassays. A commercially available system was used to determine the relative response of bioluminescent to a number of alkyltin compounds. Within a series of compounds differing only in the number of R groups attached to the central tin atom, the most toxic compound was always the trialkyltin compound. The greatest difference in toxicity was found in the butyltin series of compounds tributyltin was approx 35 times more toxic than dibutyltin and approx. 750 times more toxic than monobutyltin. When trialkyltin compounds were compared, the toxicity to these bacteria increased with the number of carbons in the alkyl chain the tributyltin compound are approx. 150 times more toxic than trimethyltin compounds. Keywords Alkyl groups Halide Bioassay.