Mechanisms of Rapid Nonspecific Resistance Induced by Immunomodulators: Delineation Using Selective Depletion of Cells. .
Final progress rept.Aug 86-Jul 87,
MEDICAL COLL OF PENNSYLVANIA PHILADELPHIA DEPT OF MICROBIOLOGY AND IMMUNOLOGY
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The effects of a wide variety of endogenous and exogenous immunomodulators were applied in mouse models permitting in vivo and in vitro analysis of effector mechanisms in rapid non-specific resistance. Major attention was given to models in which circulating monocytes and NK cells were depleted in short-term and long-term administration of the bone-seeking isotope, strontium. Techniques for the use of free and liposome-encapsulated cytotoxins were studied in vitro and in vivo. Toxins included ricin, ricin A-chain and dichloromethylene diphosphonate DMDP. Keywords Macrophages, Monocytes, Listeria, Immunotherapy, Interferons, Immunomodulators, Bone marrow depletion, Liposomes, Prostaglandins, Ricin, Ricin A-chain, Dichloromethylene diphosphonate.
- Medicine and Medical Research