Accession Number:

ADA191430

Title:

Mechanisms of Rapid Nonspecific Resistance Induced by Immunomodulators: Delineation Using Selective Depletion of Cells. .

Descriptive Note:

Final progress rept.Aug 86-Jul 87,

Corporate Author:

MEDICAL COLL OF PENNSYLVANIA PHILADELPHIA DEPT OF MICROBIOLOGY AND IMMUNOLOGY

Personal Author(s):

• Morahan, Page S.
• Volkman, Alvin

Report Date:

1988-01-28

Pagination or Media Count:

47.0

Abstract:

The effects of a wide variety of endogenous and exogenous immunomodulators were applied in mouse models permitting in vivo and in vitro analysis of effector mechanisms in rapid non-specific resistance. Major attention was given to models in which circulating monocytes and NK cells were depleted in short-term and long-term administration of the bone-seeking isotope, strontium. Techniques for the use of free and liposome-encapsulated cytotoxins were studied in vitro and in vivo. Toxins included ricin, ricin A-chain and dichloromethylene diphosphonate DMDP. Keywords Macrophages, Monocytes, Listeria, Immunotherapy, Interferons, Immunomodulators, Bone marrow depletion, Liposomes, Prostaglandins, Ricin, Ricin A-chain, Dichloromethylene diphosphonate.

Descriptors:

• *BONE MARROW
• *IMMUNOCHEMISTRY
• *LABELED SUBSTANCES
• CIRCULATION
• CYTOPLASM
• DEPLETION
• IN VITRO ANALYSIS
• IN VIVO ANALYSIS
• INTERFERON
• LISTERIA
• LONG RANGE(TIME)
• MICE
• MODELS
• MONOCYTES
• PHOSPHONATES
• PROSTAGLANDIN
• RESISTANCE
• RICIN
• STRONTIUM
• TOXINS AND ANTITOXINS
• RESISTANCE(BIOLOGY)
• TOXIC TOLERANCES

Subject Categories:

• Medicine and Medical Research
• Biochemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE