Accession Number:

ADA191002

Title:

Potential Benefits and Hazards of Humoral Immune Reactions against HTLV-III.

Descriptive Note:

Annual rept. 30 Sep 86-29 Sep 87,

Corporate Author:

KAROLINSKA INST STOCKHOLM (SWEDEN)

Personal Author(s):

• Wigzell, Hans
• Gidlund, Magnus
• Nilsson, Kenneth

Report Date:

1987-10-10

Pagination or Media Count:

18.0

Abstract:

Gp120 binding to CD4 requires beta-glycanase sensitive carbohydrate chains to retain binding ability. A 28Kd fragment of Gp120 has been identified with complete retention of CD4 binding capacity. Human monocytes can be readily infected with HIV. In the absence of anti-HIV antibodies, phagocytic or non-phagocytic monocytes are equally sensitive. Anti-HIV antibodies at certain high dilutions may enhance HIV proliferation in human monocytes although exact conditions causing such enhancement are not yet defined. Certain human HIV-seropositive individuals produce high titered antibodies which display molecular mimicry with CD4 and bind to Gp120. Such antibodies may tentatively be linked to good prognosis. Keywords Human immunodeficiency virus, Immunosuppression, Immunity.

Descriptors:

• *ANTIBODIES
• *IMMUNOSUPPRESSION
• *VIRUSES
• HAZARDS
• HUMANS
• HUMORAL IMMUNITY
• IMMUNITY
• MONOCYTES
• PREDICTIONS
• PHAGOCYTES
• MOLECULE MOLECULE INTERACTIONS
• GLYCOPROTEINS
• ANTIGENS

Subject Categories:

• Genetic Engineering and Molecular Biology
• Microbiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE