Mutagenic Potential of Nitroguanidine in the Mouse Lymphoma Forward Mutation Assay
Final rept. 11 Mar-16 Oct 1985
LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA
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The mutagenic potential of nitroguanidine was assessed in the mouse lymphoma thymidine kinase forward mutation assay both with and without metabolic activation by rat liver. In the initial range-finding assay, cells were exposed to test compound concentrations ranging from 4 milligrammilliliter to 0.01 milligrammilliliter. The confirmatory assay employed doses from 4 milligram milliliter to 1 milligrammilliliter. Nitroguanidine did not induce a statistically significant increase in the mutant frequency in either of the two assays. These results indicate that nitroguanidine was not mutagenic under the conditions of this study. Keywords Mutagenicity, Genetic toxicology, Mouse lymphoma assay, Mutagenesis, In vitro, Nitroguanidine teratology Toxic tolerances.