Characterization and Modeling of Thoraco-Abdominal Response to Blast Waves. Volume 6. Biochemical Model of Lung Injury Mechanisms
Annual rept. (Final) 15 Feb 82-31 May 85
JAYCOR SAN DIEGO CA
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A major objective of the Blast OverPressure BOP program is to understand blast injury. This includes the injury mechanisms, theories of tissue failure, determination of tissue failure strength, and prevention. With finite element model simulation, for a given blast wave loading, we are able to predict the intrathoracic overpressure histories at various points in the lung. Questions arising are What insightful information does the model prediction provide on the origin of injury How do we correlate the actual blast injury with the local overpressure predictions This report documents our efforts toward these objectives. A review of lung trauma following blast wave exposure and impact is made in Section 2. It provides a summary of lung injury descriptions in both macroscopic and microscopic terms. With this background, we then look at the model simulation of wave dynamics in the lung, identify wave propagation characteristics. A comparison between lung hemorrhage and model overpressure prediction is made. Keywords Weapons effects Occupational diseases Mathematical models Anatomical models ExposurePhysiology Ribs Pleural pressures.
- Anatomy and Physiology