Accession Number:

ADA190612

Title:

Development of a Calcifiable Matrix for Bone Formation.

Descriptive Note:

Final rept. 1 May 82-28 Feb 86,

Corporate Author:

ALABAMA UNIV IN BIRMINGHAM LAB OF MOLECULAR BIOPHYSICS

Personal Author(s):

Report Date:

1987-09-01

Pagination or Media Count:

34.0

Abstract:

As a contractual, development-synthetic effort, this project had two goals. The first was the delivery to the USAIDR of approximately 13 grams of synthetic peptide for in vivo study of calcifiability, ossification, biocompatibility and wound repair issues. The second goal was the characterization of the peptide in matrix form with respect to its in vitro calcification, stress-strain properties, biocompatibility and chemotaxis potential. This project was developmental in nature an objective was the elaboration of an off the shelf matrix for bone formation with the approach being based on a polypentapeptide. This polymer, when cross-linked into an insoluble matrix, calcified massively on exposure to normal human serum dialyzates. Keywords Peptide synthesis, Sequential polypeptides, Polymerization methods, Y-irradiation cross-linking, Cross-linked polynonapentapeptide, Chemotaxis, Wound cover, Osteogenesis.

Subject Categories:

  • Medicine and Medical Research
  • Anatomy and Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE