Three Proteins Made by Glial Cells of the Goldfish (C. auratus) Optic Nerve Undergo Increased Synthesis Following Trauma to the Optic Nerve.
Rept. for Sep 86-Jun 87,
LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA
Pagination or Media Count:
Glial cells have been shown to increase the levels of synthesis of selected proteins in response to damage inflicted upon their associated axons. These proteins may be instrumental in mediating axonal repair. In this study proteins synthesized by the glial cells of the goldfish optic nerve were examined using tissue incubation, polyacrylamide gel electrophoresis, and gel fluorography. Ten days after monocular nerve crush or monocular enucleation, three glial proteins were found to have increased levels of synthesis relative to controls. These enhanced glial proteins, or EGPs, were detectably increased relative to controls at 4.5 hr after nerve trauma, and returned to control levels of synthesis by 6 months post-crush. Keywords Nerve regeneration, Proteins, Glia, Goldfish, Optic nerve, Growth substances.
- Anatomy and Physiology