Acute Respiratory Tract Toxicity of the Trichothecene Mycotoxin, T-2 Toxin.
ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD
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The systemic toxicology of trichothecene mycotoxins in a variety of laboratory and farm animals is well documented. Toxicity reports following respiratory exposure, however, are mostly anecdotal. For instance, Ismailson first called attention to toxicosis secondary to mold spore inhalation in a binder twine factory. More recently, Forgacs described symptoms of a severe pharyngitis, or burning sensation in the nose accompanied by bloody nasal discharge and a moderate to severe cough in workers that developed stachybotryotoxicosis after inhaling dusts from Stachybotrys-contaminated straw. Ueno reported 100 lethality of five mice 5 days after a 160-minute exposure to 140 ppb of T-2 mycotoxin. However, no information on aerosol generation or aersol characterization was given, and only very limited information on exposure conditions was presented. A report issued in 1983 by the Committee on Protection Against Trichothecene Mycotoxins noted that there was a lack of information on inhalation exposure to trichothecene toxins and recommended that this route of exposure be studied. Keywords Phytotoxins.