Accession Number:

ADA190154

Title:

Beneficial Effect of Dexamethasone in Decreasing the Lethality of Acute T-2 Toxicosis,

Descriptive Note:

Corporate Author:

ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD

Personal Author(s):

Report Date:

1986-11-07

Pagination or Media Count:

23.0

Abstract:

Steroidal and non-steroidal anti-inflammatory agents were evaluated for effectiveness for treatment of acute T-2 toxicosis in mice. Non-steroidal agents, indomethacin, phenylbutazone, and acetylsalicyclic acid, were either ineffective, or potentiated the lethality of T-2 toxin. Steroidal agents, assessed at equivalent doses for anti-inflammatory activity, were all effective, with dexamethasone being more effective than either methylprednisolone or hydrocortisone. The doses of dexamethasone producing the highest efficacy were 1.0 mgkg and 12.5 mgkg for im and ip routes of administration, respectively. The mean time to death, mean survival time, and percent lethality were determined for untreated and dexamethasone-treated mice injected with a lethal dose of T-2 toxin.

Subject Categories:

  • Toxicology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE