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Accession Number:
ADA188572
Title:
Cholinergic Neurotransmission in the Mammalian Retina.
Descriptive Note:
Annual rept. (Summary) 30 Sep 84-29 Sep 85,
Corporate Author:
WAYNE STATE UNIV DETROIT MI DEPT OF ANATOMY
Report Date:
1985-11-30
Pagination or Media Count:
19.0
Abstract:
This study is directed toward the cellular localization of acetylcholine ACh and acetylcholinesterase AChE in the cat retina, elucidation of the synaptic relationships and biochemical interactions of the neurons containing these substances, and the effects of organophosphorus anticholinesterase compounds on the normal function of the cholinergic system. The cholinergic system in a mammalian cat retina is being investigated by cytochemical and biochemical techniques. The cholinergic cells have been identified through immunocytochemical localization of choline acetyltransferase is found in more types of amacrine cells than the transferase and is also present in all of the ganglion layer cells. The esterase is distributed throughout the inner plexiform layer with the heaviest concentrations at depth levels of 0-6 and 64-78. The large concentration and widespread distribution of acetyl-cholinesterase in cat retina make it a useful model in which to study the roles of this enzyme. Biochemical studies are in progress to determine the effect of acetylcholine on the release of other retinal neurotransmitters, how these other transmitters modify the release of other retinal neurotransmitters, how these other transmitters modify the release of acetylcholine, and how acetylcholinesterase influences these interactions.
Distribution Statement:
APPROVED FOR PUBLIC RELEASE
