Studies of Altered Responses to Infection Induced by Thermal Injury.
Annual progress rept. 30 Apr 84-1 May 85,
CALIFORNIA UNIV SAN FRANCISCO
Pagination or Media Count:
Sepsis is the major cause of mortality following severe injury. Immunoincompetence, involving both augmented T sub s activity and increased inh M0 function, plays an important role in the increased risk of septic complications of post-trauma patients. The objective of our studies is to define those mechanisms by which trauma could induce excessive regulatory cells and to develop prophylatic treatment which may mitigate adverse trauma-induced M0-T sub s dysfunctions. We have, therefore, concentrated our current investigation into characterizations of the types and nature of M0 aberrations which develop after trauma. In particular, we are focusing on those M0 aberrations which could contribute to the development of excessive regulatory activity.
- Medicine and Medical Research