Synthetic Helizyme Enzymes.
Annual rept. Jul 86-Jul 87,
COLORADO UNIV HEALTH SCIENCES CENTER DENVER
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The object of this project is to design and synthesize totally new, totally synthetic small molecules having specific enzyme activity. The ultimate goal is to design and synthesize a molecule with cholinesterase activity. The initial goal is to design and synthesize a molecule with chymotryspin activity. Computer-assisted molecular graphics is being used to model chymotryspin from the known X-ray structure and extract the amino acid residues responsible for catalytic activity and substrate binding. A synthetic framework of amphipathic helical peptides is being designed and will be synthesized to hold the essential amino acid residues in the conformation necessary for enzyme activity.
- Genetic Engineering and Molecular Biology