Accession Number:

ADA184413

Title:

Synthetic Helizyme Enzymes.

Descriptive Note:

Annual rept. Jul 86-Jul 87,

Corporate Author:

COLORADO UNIV HEALTH SCIENCES CENTER DENVER

Personal Author(s):

Report Date:

1987-08-18

Pagination or Media Count:

12.0

Abstract:

The object of this project is to design and synthesize totally new, totally synthetic small molecules having specific enzyme activity. The ultimate goal is to design and synthesize a molecule with cholinesterase activity. The initial goal is to design and synthesize a molecule with chymotryspin activity. Computer-assisted molecular graphics is being used to model chymotryspin from the known X-ray structure and extract the amino acid residues responsible for catalytic activity and substrate binding. A synthetic framework of amphipathic helical peptides is being designed and will be synthesized to hold the essential amino acid residues in the conformation necessary for enzyme activity.

Subject Categories:

  • Genetic Engineering and Molecular Biology
  • Biochemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE