The Effect of an Experimental Missile Wound to the Brain on Brain Electrolytes, Regional Cerebral Blood Flow and Blood Brain Barrier Permeability.
Annual rept. 1 Jul 84-31 Dec 85, Final rept. 1 Jul 83-31 Dec 85,
LOUISIANA STATE UNIV MEDICAL CENTER NEW ORLEANS
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Brain wounds account for most deaths on the battlefield yet scarcely any research has been done on brain wounds caused by missiles. The purpose of this research was to develop a valid laboratory model of a brain wound and to study several clinically important physiologic variables altered by wounding. Better adjunctive medical treatments for brain wounds will be developed once the pathophysiology of brain wounding is understood. We have a laboratory model for painlessly creating a uniform brain wound in anesthetized cats and have studied several physiologic variables altered by brain wounding. We make the brain wound by a helium powered gun which fires a 2mm diameter, 31mg, steel sphere across a velocity gate and through a cats intact skull. Prior to wounding, the cat is precisely positioned in front of the gun in a stereotaxic frame. Missile energy is calculated from measured velocity.
- Weapons Effects (Biological)