Accession Number:

ADA184068

Title:

Primary Eye Irritation of Guanidine Hydrochloride in Rabbits

Descriptive Note:

Final rept. 3 May-9 Jun 1984

Corporate Author:

LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA

Report Date:

1987-07-01

Pagination or Media Count:

32.0

Abstract:

The primary eye irritation potential of guanidine hydrochloride was determined in male New Zealand White rabbits using a modified Draize method. The compound produced irritation in all animals tested. Signs of irritation were erythemaz and chemosis of the conjunctiva, iritis, and corneal lesions. These results indicate that guanidine hydrochloride should be classified as an ocular irritant. Keywords Primary Eye Irritation, Guanidine Hydrochloride, Mammalian Toxicology ogy, Nitroguanidine, Munition, Explosives, Rabbit.

Subject Categories:

  • Toxicology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE