Accession Number:

ADA183835

Title:

Design and Synthesis of Candidate Prophylactic and Therapeutic Compounds for Use in the Management of Organophosphorus Poisoning.

Descriptive Note:

Annual progress rept. no. 3, 1 Sep 83-30 Sep 84,

Corporate Author:

ASH STEVENS INC DETROIT MI

Personal Author(s):

• Blumbergs,P.
• Knutson,P. L.
• Priest,M. A.
• Kalamas,R. L.
• Vonk,G. P.

Report Date:

1985-01-01

Pagination or Media Count:

76.0

Abstract:

The program is directed at the design and synthesis of new compounds for use in the management of organophosphorus poisoning. In the past year 24 compounds were submitted 12 organophosphinates, one organophosphinic acid, one organophosphinothioate, one organophosphonate, 3 organophosphates, 2 ferrocene carbamates, one each 2-aminoethylseleninic and selenonic acids, phenyl valerate and 2,2-dimethyl-3-hydroxybutylamine. The purpose of the contract is to maintain and operate a synthesis laboratory to provide chemical compounds needed in the development programs of the U.S. Army Medical Research Institute of Chemical Defense ICD Edgewood Area, Aberdeen Proving Ground, Maryland.

Descriptors:

• *ANTIDOTES
• *SYNTHESIS(CHEMISTRY)
• *PREVENTIVE MEDICINE
• ACIDS
• CHEMICAL COMPOUNDS
• MANAGEMENT
• ORGANIC PHOSPHORUS COMPOUNDS
• POISONING
• LABORATORIES
• SYNTHESIS
• ARMY RESEARCH
• MEDICAL RESEARCH
• CHEMICAL WARFARE
• DEFENSE SYSTEMS
• CARBAMATES
• PHOSPHONATES

Subject Categories:

• Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE