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Field Applicable Method to Reduce Dental Emergencies.

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Final rept. 1 Sep 78-30 Sep 83,

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In vitro experiments have shown that twice daily exposure of S. mutans to various fluoride salts has shown that only SnF2 significantly alters this organisms growth and metabolism. The antibacterial effect of SnF2 was associated with an uptake of tin into the bacteria. Fluoride salts of sodium, lead, zinc, and copper had little effect in the test system. The pH of the various fluoride salts generally had no effect on the test compound activity except for the noted inactivation of SnF2 at elevated pHs. Since SnF4 also did not affect the growth of metabolism of S. mutans, a unique property of SnF2, possibly its reactivity in an aqueous environment, may be responsible for its antibacterial properties. Stannous fluoride was compared to NaF 5 ppm F- in the drinking water of hamsters to test whether SnF2 had greater caries inhibitory effects due to its potential antibacterial effects. The number of enamel and dentinal carious lesions in both the NaF and SnF2 group was significantly different from the deionized water group however, there was no difference in caries scores between the NaF and SnF2 group. The recovery of S. mutans was highly variable between animals and showed no statistical difference between groups. The subjects rinsing with SnF2 developed approximately half the number of new carious lesions to those subjects rinsing with acidulated NaF. The lower frequency of bleeding sites and the corresponding lower mean GI scores in the SnF2 group compared to the NaF group demonstrates that rinsing with SnF2 favorably affected gingival health.

Subject Categories:

  • Medicine and Medical Research
  • Pharmacology

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