Accession Number:

ADA183649

Title:

Structure and Design of Multipotent Peptide Microbicides.

Descriptive Note:

Annual rept. 1 Aug 86-1 Aug 87,

Corporate Author:

CALIFORNIA UNIV LOS ANGELES DEPT OF MEDICINE

Personal Author(s):

• Selsted,Michael E.

Report Date:

1987-08-01

Pagination or Media Count:

8.0

Abstract:

A family of antimicrobial leukocyte peptides has been iolated from the neutrophils of several species. I am using the concensus structure of the peptides known as defensins as a molecular foundation for generating new antimicrobial peptides by synthetic methods. The synthetic approach is directed by correlating the solution structures of various defensins with their distinctive bilogical activities. Report consists of a brief description of recent accomplishments.

Descriptors:

• *LEUKOCYTES
• *PEPTIDES
• *ANTIMICROBIAL AGENTS
• ANTIMICROBIAL AGENTS
• LEUKOCYTES
• PEPTIDES
• POLYMORPHONUCLEAR NEUTROPHILS
• SYNTHESIS(CHEMISTRY)
• MOLECULAR STRUCTURE

Subject Categories:

• Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE