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Biological Applications and Effects of Optical Masers
Annual final rept. 16 Mar-15 Oct 1986
VIRGINIA COMMONWEALTH UNIV RICHMOND
Pagination or Media Count:
The literature pertaining to retinal light damage from environmental and man-made optical sources prior to the last decade is reviewed with particular attention to acute and long-term chronic exposure leading to thermal and photochemical lesions of the retina. The parameters of wavelength, exposure time and power level are given as the major factors defining thermal vs photochemical damage. Light toxicity as a function of wavelength is dealt with in some detail. In particular, wavelengths ranging from 1064 nm to 325 nm in the near ultraviolet are studied using macaque monkeys. Exposures in the near UV were accomplished using aphakic monkeys lens removed surgically. The histopathologies of blue light and near ultraviolet lesions of the retina in the macaque monkey are described. Light damage to the RPE and its possible relationship to aging and macular degeneration is investigated. Keywords Light toxicity Wavelength dependence Solor retinitis Oxygen radicals and photodynamic action Pulse train thresholds Laser safety standards Anti-oxidants.
APPROVED FOR PUBLIC RELEASE