Accession Number:

ADA183462

Title:

Biological Applications and Effects of Optical Masers

Descriptive Note:

Annual final rept. 16 Mar-15 Oct 1986

Corporate Author:

VIRGINIA COMMONWEALTH UNIV RICHMOND

Personal Author(s):

• Ham, Jr., William T.
• Mueller, Harold A.
• Ruffolo, Jr., John J.
• Cleary, Stephan F.
• Guerry, III, R. K.

Report Date:

1987-04-01

Pagination or Media Count:

48.0

Abstract:

The literature pertaining to retinal light damage from environmental and man-made optical sources prior to the last decade is reviewed with particular attention to acute and long-term chronic exposure leading to thermal and photochemical lesions of the retina. The parameters of wavelength, exposure time and power level are given as the major factors defining thermal vs photochemical damage. Light toxicity as a function of wavelength is dealt with in some detail. In particular, wavelengths ranging from 1064 nm to 325 nm in the near ultraviolet are studied using macaque monkeys. Exposures in the near UV were accomplished using aphakic monkeys lens removed surgically. The histopathologies of blue light and near ultraviolet lesions of the retina in the macaque monkey are described. Light damage to the RPE and its possible relationship to aging and macular degeneration is investigated. Keywords Light toxicity Wavelength dependence Solor retinitis Oxygen radicals and photodynamic action Pulse train thresholds Laser safety standards Anti-oxidants.

Descriptors:

• *RETINA
• *EXPOSURE(PHYSIOLOGY)
• *MASERS
• *RADIATION EFFECTS
• *LASER DAMAGE
• FREQUENCY
• POWER LEVELS
• SOURCES
• OPTICAL PROPERTIES
• ENVIRONMENTS
• BIOLOGY
• PHOTOCHEMICAL REACTIONS
• LASER SAFETY
• MACAQUE MONKEYS
• NEAR ULTRAVIOLET RADIATION
• CHEMICAL RADICALS
• LESIONS
• BLUE(COLOR)
• TOXICITY
• LIGHT
• LONG RANGE(TIME)
• TIME
• OXYGEN
• MANMADE
• STANDARDS

Subject Categories:

• Radiobiology
• Stress Physiology
• Lasers and Masers

Distribution Statement:

APPROVED FOR PUBLIC RELEASE