Development of Synthetic Catalysts for Peptide Bond Cleavage (Synthesis and Complete Kinetic Analysis of Compounds 6A, 7A, 8A).
Annual rept. 6 Aug 86-5 Aug 87,
KANSAS UNIV LAWRENCE
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Synthetic mimics for carboxypeptidase A will be synthesized and the structural and chemical factors responsible for catalytic peptidase activity will be probed. Ditopic macrocyclic receptors have been designed which incorporate the salient features of the enzyme analog, namely high affinity complex formation, general base and general acid catalysis, and covalent catalysis. Once synthesized the resulting macrocycle-metal ion complexes should non-specifically promote the hydrolysis of C-terminal peptide bonds. The initial macrocycles, ammonium and ether oxygens. One side of ditopic receptor will preferentially bind zinc II ion, the other the peptide substrate.
- Organic Chemistry