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Effect of Ionizing Radiation on Prostaglandins and Gastric Secretion in Rhesus Monkeys
UNIFORMED SERVICES UNIV OF THE HEALTH SCIENCES BETHESDA MD DEPT OF MEDICINE
Pagination or Media Count:
The radiation induced prodromal syndrome is characterized by nausea and vomiting. Gastric emptying, gastric motility, and gastric secretion were suppressed after total body exposure to irradiation. The relation between vomiting and gastric function, is evaluated and the possible role of prostaglandins PG in these phenomenons is explored. The concentration of PG in the plasma and gastric juice was determined using standard radioimmunoassay and gastric acid output was concurrently measured using a marker dilution techniques in 9 rhesus monkeys. The animals were studied in the basal state and after total body exposure to 800 cGy Cobalt-60 delivered at a rate of 500 cGymin. Acid output was abolished from 40 min to 2 hrs after irradiation but had returned to preirradiation levels 2 days later. Plasma PGE2 and PGI2 were not significantly modified by irradiation. In contrast, irradiation produced an immediate increase p0.05 in gastric juice concentration of PGE2 and PGI2 both had returned to basal levels 2 days later. Thus, both PGE2 and PGI2 may be responsible for the immediate suppression of acid output. Observations suggest that measurement of PG concentration in the gastric juice is useful to examine the role of prostaglandins in gastric function.
APPROVED FOR PUBLIC RELEASE