The Synthesis and Study of Azole Carboxamide Nucleosides as Agents Active Against RNA Viruses.
Final rept. 1 Apr 79-31 Aug 85, Annual rept. 1 Sep 84-31 Aug 85,
BRIGHAM YOUNG UNIV PROVO UT
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In an effort to prepare compounds with potential antiviral activity against RNA viruses having substantial implications from a global epidemiological standpoint, a number of azole heterocycles and the corresponding nucleosides structurally related to ribavirin have been synthesized. 1,2,4-Triazole, thiazole, pyrrole, pyrazole, purine, pyrrolo2,3-d pyrimidine and pyrimido5,4-d pyrimidine ring systems have particularly been selected. New and improved synthetic procedures have been developed during the course of this study. The compounds thus synthesized in gram quantities were tested at the U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, against RVF, VEE, PITCH, YF, SF, VSV, and KHF viruses in vitro and in vivo. Keywords Ribaviran, Rift Valley fever virus Lass virus Machupovirus Dengue virus Pichinde virus Hantaan virus Retroviruses.