Experimental Studies of Arenaviral Hemorrhagic Fevers,
ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD
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Three arenaviruses, Lassa, Junin, and Machupo, regularly cause serious disease when they infect humans Lassa fever, Argentine hemorrhagic fever AHF, and Bolivian hemorrhagic fever BHF, respectively. There is increasing acceptance that these and other human viral infections share sufficient, common, clinical and pathophysiological findings to refer to a viral hemorrhagic HF syndrome JOHNSON and PETERS 1985. This entity is characterized by fever, malaise, prostration, and evidence of diffuse vascular dsyregulation and permeability changes. Hemorrhagic manifestations occur in many cases, usually in proportion to the gravity of the illness and the prognosis. The mechanisms underlying these clinical events probably vary depending on the infecting virus, but almost certainly share common themes PETERS and JOHNSON 1984. The biohazard of the causative viruses, the difficult logistics of clinical research in the regions where most HFs occur, and the limited international support for research on so-called exotic viruses have all been important barriers to progress in the field.
- Medicine and Medical Research