Accession Number:

ADA181809

Title:

Port-Wine Nevus-Like Arteriovenous Malformation in a Rhesus Monkey (Macaca mulatta),

Descriptive Note:

Corporate Author:

OHIO STATE UNIV COLUMBUS DEPT OF PATHOBIOLOGY

Report Date:

1987-01-01

Pagination or Media Count:

4.0

Abstract:

A nevus is a circumscribed developmental defect of the skin that may or may not be congenital and can form from any of more integumentary consituents. Port-wine nevus is a red-to-purple blemish resulting from telangiectatic capillaries in the dermis, and usually a macule or patch, but can become raised with age. It most often occurs on the face, sometimes covering large areas, and is present at birth. Neviod arteriovenous A-V angiopathy, a distinct human clinical entity, is also found on the face and other locations. Variants of this lesion have been referred to as acral arterio-venous tumor, venous hemangioma or phlebangioma, and A-V shunt. It is usually an acquired, red-to-purple papule or nodule, 1 to 30 mm in diameter, consisting of endothelial-lined, thick-walled and thin-walled fibromusclar vascular channels located in the superficial and middle dermis. Although the classification and histogensis of this tumor is controversial, many authors believe that it is a dysplasi and not a true angioma. Spontaneous cases of these skin conditions have not been reported in monkeys. We describe a vascular nevus in the rhesus, Macaca mulatta, with a combination of clinicopathologic features of port-wine nevus and nevoid A-V angiopathy that occur in man.

Subject Categories:

  • Animal Husbandry and Veterinary Medicine
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE