Further Evidence That Stress Hyperthermic is a Fever,
MICHIGAN UNIV ANN ARBOR DEPT OF PHYSIOLOGY
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Exposure of rats to an open-field results in a rapid rise in body temperature. Fifty-four percent of this rise in body temperature was blocked by intracerebroventricular administration of the antipyretic drug sodium salicylate. Intraperitoneal administration of indomethacin, a potent blocker of prostaglandin production, also attentuated the stress-induced hyperthermia to the same degree. Based on the data presented in this an earlier study, we conclude that a major component of the rise in body temperature induced by psychological stress in rats is mediated by prostaglandins released by the central nervous system, and may therefore be a fever. Keywords Hyperthermia Interleukin-1 Temperature regulation StressPhysiology Reprints.
- Medicine and Medical Research